Questions regarding your treatment

[Krikkit]

Hi everyone, just thought I might post this in here.. I am on CD11

do these dosage amts sound high?

Puregon 225iu everyday, orgalutran 0.5ml everyday and pregnal 0.1ml every second day.

When should I expect epu? and is it normal to have ewcm now?

Thanks!

[Lovenhope]

Hi Krikket,
Sorry I can't help with the dosage but I had tonnes of EWCM during stimming.

[Acacia]

Hi Krikkit,

I can't tell you about Orgalutran or Pregnyl as I have not had a stim cycle protocol using these drugs myself (other than Pregnyl for triggering ovulation) but I can tell you that the dose of Puregon you are on is a fairly normal dosage.

There is a real range of "normal" in terms of dosage for FSH, and it completely depends on the individual and things like your weight, how sensitive your FS thinks you may be to responding and even your previous response to the drug if you've had a previous cycle etc. but in my first IVF cycle I was on 225 like you (except I was on Gonal-F instead of Puregon). I know that 225 would be a higher dose for some women but not necessarily for others - in my next cycle my dosage went up to 262.5.

I would think it's normal to have EWCM at CD11, especially if it is more than you are used to as your other cycle hormones are being triggered much more than normal when you are on Puregon - I used to like to think I was having a "super cycle".

EPU will depend on how your follicles are developing and how your oestrogen levels are doing. You'll be advised when it will be with a couple of days notice, when you are told to take your trigger injection. I don't know whether you have a normal cycle when you're not doing an IVF stim cycle, but I found that my EPU was always a little bit later than my normal ovulation time, which CD15 for me. It'll certainly be around the CD14 time, but could be a bit later by a number of days - all depends on your response.

HTH, and much good luck with your cycle! Fingers crossed for lots of good mature eggs!


Miss C

[Lovenhope]

miss c- you are a tower of knowledge

[Taurean78]

Hi there,

I had a Hyst & Lap performed today and found that my tubes are clear but they are adhered to my ovaries, meaning a natural BFP is unlikely. Not impossible - just really challenging.

TIA

Since my surgery 3 weeks ago today, I have still not had AF turn up. I am on day 32 and my longest cycle prior to this was 30 days - averaging 28. Is it normal for these kinds of procedures to muck up your cycle? I bled for about 4 days after the surgery from the hyst.
I have PMS - big time crankiness and lovely chin zits but nothing to match it!!!! For once I want it to turn up and be done with it. Any advice appreciated

[worrywart]

Hi there,
Bit new to posting, so hopefully someone reads this. I just got a negative blood test at 19 days post-IUI (#2). It's just odd, because I still haven't started my period, and I've never been this late. I did have Pregnyl (1500) on days 4 and 8 (post IUI). But last cycle, I got my period bang on 15 days post-IUI, with the same protocol.
I just have no idea when my next cycle will start now. Has anyone else had their cycle delayed and by how much? The nurse was very non-specific, like "just wait". It's not very comforting. Any advice?

[anney]

Hi Worrywart, Unfortunately your nurse is probably correct - you do have to "just wait". the hormones impact everyone's bodies to a different extent and things can vary with one person from one cycle to the next, so really no-one can predict when Af will arrive. Were you having progesterone as well? that can often delay AF.

[worrywart]

Hi Anney,
Thanks so much for your reply. I'm sure you're right. I've never had a really delayed AF (even on clomid) so this is a new experience for me. Nope, I wasn't on progesterone. Sometimes it's tempting to speculate on "Why?" etc but I guess I am just looking forward to the start date of a new cycle.
Anyway, thanks again and best of luck for your own treatments.

[happymel]

I am not sure where exactly this post belongs, so i will try here and hopefully not offend anyone. I was wondering, for those going through ivf second time round, are you allowed to BF whilst doing a FET?? I am thinking not, but have a FS appt in a couple weeks. If the FET doesnt work then we will wait for another 18 months or so before doing a full cycle again and it will be disappointing to stop BF'ing.
Thanks Mel

[butterfly_warrior]

Everything I have seen, read and heard is a resounding no. The drugs used in FET cycles aren't safe while breastfeeding. Even if you are having natural cycles, they believe that the BF hormones will act against implantation.

BW

[happymel]

Thanks BW. Pretty much thought so. I wonder how long i will have to stop BF'ing for before the t/f. Lots of questions to ask FS. Poor DS he loves his booba!

[JustOneMore]

Double Posting

[JustOneMore]

Hi,

I have a couple question regarding NK Cell test and what the results mean.

Question No 1: Total NK Cells (CD3- 56+), What percentage level is classed as normal.

On My sisters test result her level was 19.8% and they said that was classed as Very Very High levels. She requires Prednisilone and Clexane for her future IVF cycles.


Question No. 2: On my results for the NK Test there was hand writing on my test from lab regarding, Activited (CD69+) dim NK’S, does anyone know anything about this?
A lot of the NK tests do not have this information written on it as it is only done if your doctor specifically requests it and if they specialises in immunology.

Mine reads as Activited (CD69+) dim NK’S = 2-1% = 4.2 x 10 6/L

Does anyone know what percentage this should be and what percentage rate is considered as high and low.


Quote:
Originally Posted by Inanna View Post
The NK cell is the most abundant immune cell infiltrating the womb implantation site. In a previous study, an elevated percentage of peripheral blood NK cells were associated with recurrent failed IVF-ET treatment cycles. Another study showed that increased peripheral blood NK cell toxicity was associated with an increased rate of recurrent failed implantation after IVF-ET treatment. More recent studies have confirmed elevated NK cell CD69 expression as being associated with recurrent miscarriage and infertility of unknown reason.

I also found this on a UK site: But I don’t know if there tests are done differently to ours:

• The NK cell is the most abundant immune cell infiltrating the womb implantation site. In a previous study, an elevated percentage of peripheral blood NK cells were associated with recurrent failed IVF-ET treatment cycles. Another study showed that increased peripheral blood NK cell toxicity was associated with an increased rate of recurrent failed implantation after IVF-ET treatment. More recent studies have confirmed elevated NK cell CD69 expression as being associated with recurrent miscarriage and infertility of unknown aetiology. Finally, a recent small non-randomised study has also suggested elevated NK cell CD69 expression may be related to failed implantation of the embryo.

We also recently conducted a study to evaluate the effect of the absolute count of the activation marker (CD69) and inhibitor marker (CD94) expression on peripheral blood NK cells on implantation and miscarriage rates after IVF-ET treatment. It was a randomised prospective observation study of 138 randomly selected women who underwent IVF-ET treatment from December 2002 to September 2003. Our data suggests that an elevated level of CD69+ peripheral blood NK cells is a detrimental factor for implantation of embryos in IVF-ET treatment. Those women who have an elevated peripheral blood CD69+ NK cell count achieve a positive pregnancy from IVF-ET have a significantly higher risk of miscarriage. The specificity and positive predictive value of predicting IVF-ET outcome for women who have a peripheral CD69+ NK cell count above 1.0 x10 6 /L are 92.1% and 92.3% respectively. This test may therefore be used in clinical practice to predict negative outcome of IVF-ET treatment.

Any information is greatly appreciated.

[marcellus]

Everything I have seen, read and heard is a resounding no. The drugs used in FET cycles aren't safe while breastfeeding. Even if you are having natural cycles, they believe that the BF hormones will act against implantation.

BW

Just saw this - I actually found a study that found that it is not necessary to wean completely if you have regular, natural cycles. FS's will disagree most likely.