Immunology Prothrombin Gene/ NK Cells /Medication

[matilda2]

Hi

I have the prothrombin gene was given clexane
NK cells 9.5% was given no medication


1 IUI Failure
1 IVF ICSI Failure
1 IVF ICSI Assisted Hatching Failure


NK cells 9.5% Total B/T

Im sure my problem is implantation what medication will help?
any advice would be appreciated


IVF SUCKS BIG TIME

[Baby Dreamtime]

Hi Matilda,
Sorry to hear you have had a few unsuccessful attempts. I tested + for MTHFR which also falls under the thrombophilla blood clotting disorders. I found this out just before my 6th ET.

My treatment was with mega dose folate, B6, B12, low dose aspirin and my FS recommended Clexane from ET. I did an FET a week later, too early perhaps, it was a BFN. 2 months later I started an antagonist cycle however under stimmed, it was converted to IUI, I had a low hcg level of 9 on BT day, though classified as a chemical pregnancy it was my first ever. I only sneakily did Clexane every second day from O day (as my FS had not prescribed for an IUI cycle).

A month later I did another antagonist cycle, I did Clexane from the night of EPU, I got a BFP, fingers crossed, it looks like twins. This was my 7th ET.

I did try the Colorado Protocol early Jan which included Prednisone, and stayed on Prednisone on a low dose since then, while not cycling at 6.25mg per day (quarter tablet) just in case of NK Cells (though tested neg on BT, I never did a biopsy but my FS was happy for me to continue).

Make sure that your implantation failure blood tests are complete, I initially had one missing which I later tested + for. Also tested thyroid levels, TSH, T3 and T4, they were a little off so took thyroid support.

This is what I did this cycle:
Low dose aspirin, mega folate, B6 and B9 for MTHFR
Clexane from night of EPU (my thought was that by a Day 5 ET, it was a little too late).
Prednisone - I had 25mg tablets, CD1 to trigger quarter tablet (6.25mg), from trigger for 5 days (full tablet 25mg), then from there half tablet (12.5mg - in previous cycles I had dropped back to 6.25mg) - I had been on Prednisone since Jan 09.
I did assisted hatching for the first time, I had previously never had a hatching blastie.
This was the only cycle that I did NOT use Embryo Glue
This was the only cycle that I did NOT do acupuncture the day of ET, I had 1 treatment the afternoon of the day after (weekly treatments in the lead up).
I stopped taking Sharkey's herbs in Feb 09 after being on them for two years.
And the only cycle I had no caffeine at all from from CD1

Are you also on low dose aspirin as well as the Clexane?

I hope this helps some, I know how frustrating it is, however please keep in mind that the majority of women have success after 3-4 transfers with out having anything wrong or any issues, so it may still be a numbers game for you. I wish you all the best. xx

[matilda2]

Hello Baby Dreamtime

Thanks for your reply and advice
I have failed 2 ivf cyles and 1 iui age 40+ and im stuck at a crossroad and devastated about the last ivf attempt just finished yesterday with pregnancy blood test negative.
I have had immunology blood test plus the usual blood tests when i asked for them 12 vials on one day they even tested Nk cells but the only thing they found was prothrombin gene and was put on clexane with this last ivf icsi after egg collection the 2 weeks wait.

My 2 attempts at egg collection only few eggs collected none to freeze but were great all fertilised even going to blast with first ivf icsi, doctor was thrilled when i had 5 day blast 100 cell... my problem is Implantaion im sure of it sick sence but was not put on anything other than clexane.

Whats with oldies having good quality eggs so the Infertility specialist says my hopes so high than implantaion failure so heart renching.

Dr protocol Antagonist Cycles Gonal F 11days stim with Orgalutran 6 days double dose because i was over riding the drugs i guess no ovulation problems there, clexane night of EC, progesterone pessaries 200mg x2 am pm afer EC Till HCG Blood test.
Blood test HCG below 2 progesterone 140 BFN

Donor eggs dont want to go there husbands not willing and why would i have to go that route if the ferility specialist tells me my eggs embryo are good quality.
IF IVF ICSI Assisted Hatching Fails you what then??????
FSH 8
LH 7
Oestradiol 92
Insulin Fasting 11
Homocysteine 6.2
NK cells Total 9.5%
Prothrombin gene
MTHFR not dected
Thyroid Antibodies Thyroglobin Ab <20
Thyroid Peroxidase Ab <10


I wish my fertility specialist gave something for implantation im sure thats what my problem is on my 2 week wait i was getting night sweats around my neck my t/shirt was soaked and my temperature of an evening was 37.5 i was on progesterone but i couldnt help thinking my immune was fighting the embryo to invade anyways although my ivf icsi assisted hatching cycle just ended it was a 3dt x2embryos 8 cell and over embryologist said embys were very good quality...

Ive herd of Prednisone wonder if that would of help me in my stim protocol
No the doctor did not have me on low dose aspirin!


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